Swiss-Prot: Juggling between evolution and stability
نویسندگان
چکیده
We describe some of the aspects of Swiss-Prot that make it unique, explain what are the developments we believe to be necessary for the database to continue to play its role as a focal point of protein knowledge, and provide advice pertinent to the development of high-quality knowledge resources on one aspect or the other of the life sciences.
منابع مشابه
Removing Redundancy in SWISS-PROT and TrEMBL
SUMMARY One of the distinguishing criteria of the SWISS-PROT protein sequence data bank is minimal redundancy. The introduction of TrEMBL as a supplementary database ensured the comprehensiveness of SWISS-PROT and TrEMBL but introduced some degree of redundancy. We developed a strategy to identify the redundancy present within and between SWISS-PROT and TrEMBL and its subsequent removal. AVAI...
متن کاملDatabase verification studies of SWISS-PROT and GenBank
PROBLEM STATEMENT We have studied the relationships among SWISS-PROT, TrEMBL, and GenBank with two goals. First is to determine whether users can reliably identify those proteins in SWISS-PROT whose functions were determined experimentally, as opposed to proteins whose functions were predicted computationally. If this information was present in reasonable quantities, it would allow researchers ...
متن کاملThe SWISS-PROT protein sequence data bank, recent developments
SWISS-PROT [1] is an annotated protein sequence database established in 1986 and maintained collaboratively, since 1988, by the Department of Medical Biochemistry of the University of Geneva and the EMBL Data Library [2]. The SWISS-PROT protein sequence data bank consist of sequence entries. Sequence entries are composed of different lines types, each with their own format. For standardization ...
متن کاملTechnical comment to "Database verification studies of SWISS-PROT and GenBank" by Karp et al
In their paper “Database verification studies of SWISSPROT and GenBank” Karp et al. (2001) conclude: (1) “SWISS-PROT is more incomplete than we expected. . . ”; (2) “Even if we combine SWISS-PROT and TrEMBL, some sequences from the full genomes are missing from the combined dataset”; (3) “In many cases, translated GenBank genes do not exactly match the corresponding SWISS-PROT sequences, . . . ...
متن کاملThe SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases. Recent developments of the database include format and content enhancements, cross-r...
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ورودعنوان ژورنال:
- Briefings in bioinformatics
دوره 5 1 شماره
صفحات -
تاریخ انتشار 2004